spina

We have hosted the application spina in order to run this application in our online workstations with Wine or directly.

Quick description about spina:

SPINA is software for the rapid, reliable and accurate determination of constant structure parameters of endocrine feedback control systems. It is a class of static function tests that require nothing more than steady-state concentrations of hormones or metabolites obtained in vivo.

The first version of this cybernetic approach had been developed for the evaluation of the functional status of the thyroid gland, i.e. thyroid's secretory capacity (gain of thyroid, GT or SPINA-GT) and sum activity of peripheral deiodinases (GD or SPINA-GD).

A second version has been established for insulin-glucose homeostasis. It delivers the secretory capacity of pancreatic beta cells (SPINA-GBeta), an estimate for the insulin receptor amplification (SPINA-GR) and a static disposition index as a measure for the loop gain of the feedback loop (SPINA-DI).

Both implementations of SPINA have been validated in more than 50 clinical studies based on large cohorts.

Features:

• More than 25 years of continued development
• Based on published parametrically isomorphic models of thyroid and insulin-glucose homeostasis
• Algorithms evaluated in more than 50 clinical trials with thousands of patients
• Suport for different units of measurement
• Data import and export in HL7 format
• Curated by SciScrunch, OpenAIRE and Zenodo
• Cross-platform for macOS, Windows and Linux
• DOI 10.5281/zenodo.3596049 https: //doi.org/10.5281/zenodo.3596049 (SPINA Thyr)
• DOI 10.5281/zenodo.15249620 https: //doi.org/10.5281/zenodo.15249620 (SPINA Carb)

Audience: Healthcare Industry, Science/Research, Education, End Users/Desktop, Other Audience.
User interface: Gnome, Win32 (MS Windows), Cocoa (MacOS X), Handheld/Mobile/PDA, Carbon (Mac OS X).
Programming Language: Pascal, Delphi/Kylix, Object Pascal, S/R, Lazarus, Free Pascal.
Database Environment: XML-based, Flat-file.

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