allelome pro

We have hosted the application allelome pro in order to run this application in our online workstations with Wine or directly.

Quick description about allelome pro:

Detecting allelic biases from high-throughput sequencing data requires an approach that maximises
sensitivity while minimizing false positives. Here we present Allelome.PRO, an automated userfriendly
bioinformatics pipeline, which uses high-throughput sequencing data from reciprocal crosses
of two genetically distinct mouse strains to detect allele-specific expression and chromatin
modifications. Allelome.PRO extends approaches used in previous studies that exclusively analysed
imprinted expression to give a complete picture of the �allelome� by automatically categorising the
allelic expression of all genes in a given cell type into imprinted, strain-biased biallelic or noninformative.
Allelome.PRO offers increased sensitivity to analyse lowly expressed transcripts, together
with a robust false discovery rate empirically calculated from variation in the sequencing data.

Audience: Science/Research.
User interface: Command-line.
Programming Language: Unix Shell, Perl, S/R.

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